Hypothalamus, anterior pituitary and adrenal cortex

Stress axis (HPA)

The stress axis: three tiers, one brake.

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this pathway

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Net yieldStress in, cortisol out: glucose mobilized, inflammation damped

Steps3

The three tiers

CRH → ACTH → Cortisol: hypothalamus, pituitary, adrenal cortex

Adrenal cortex layers

GFR: salt, sugar, sex. The deeper you go, the sweeter it gets