Cytosol (liver and muscle)

Glycogenolysis

Stored glucose back out, one phosphorolysis at a time.

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this pathway
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Net yield~90% as G1P at zero ATP cost · ~10% free glucose from branch points
Rate-limitingGlycogen phosphorylase
Steps5
Irreversible3 of 4 reactions
Glycogen storage diseases I · II · III · V
Very Poor Carbohydrate Metabolism
V = Von Gierke (I), no glucose-6-phosphatase · P = Pompe (II), no lysosomal acid α-glucosidase · C = Cori (III), no debranching enzyme · M = McArdle (V), no muscle glycogen phosphorylase
Branch enzymes
ABCD: Andersen = Branching, Cori = Debranching